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Acoustophoretic tissue engineering

Vascularization with acoustics

Principle
  • Create microvasculature by locally aggregating blood vessel cells in a row using
    surface acoustic wave (SAW)
Research contents
  • Optimize the formation of capillaries by altering the physical environment of vascular cells
  • Collaborative research with the medical school to develop a patient-specific cell therapy testing platform
Figures
  • Acoustic techniques for fabricating vascular tissues
  • Artificial vessels for tissue regeneration
  • Vascularization of patient-derive dcancer organoids
  • Fluorescent bead perfusion in vascular studies

  • Acoustic techniques for fabrication
    of vascular tissues

  • Artificial vessels for tissue regeneration

  • Vascularization of patient-derived
    cancer organoids

  • Fluorescent bead perfusion in vascular studies

Functional tissues using acoustic cell patterning

Principle
  • Fabrication of functional tissues for therapeutic application
Research contents
  • Geometric alignment and aggregation of cells using acoustofluidic techniques
  • Enhancement of functions of therapeutic cells, such as stem cells, by the acoustic arrangement of cells

  • Principle of aggregating various cells using standing waves

  • Functional artificial muscle tissue fabricated using acoustic waves

Artificial vascular tissue construct

Principle
  • Regulation of geometry and structure of artificial vascular tissue using acoustic wave
Research contents
  • Manipulating acoustic wave by adjusting resonance frequencies
  • Noninvasive alignments of mammalian cells using surface acoustic wave (SAW)
  • Quantitative analysis of the geometry and structure of artificial tissue
  • Application as a drug testing platform
Figures
  • Real-time observation of aligned cell movements
  • Structure of patterned blood vessels

  • Real-time observation of aligned cell movements

  • Structure of patterned blood vessels

Blood vessel-on-a-chip for biomechanics

Principle
  • Development of acoustophoretic 3D microvascular platforms that recapitulate biomechanical environments
Research contents
  • Analysis of the influence of pressure gradients on in vitro blood vessel constructs
  • Characterization of the biomechanical properties of blood vessel tissues
  • Design of various hydrogel scaffolds to enhance cell-matrix interactions for the long-term maintenance of blood vessels
Figures
  • A schematic illustration of dynamic biomechanical environments
  • Fluorescent microbead perfusion test for functionality of blood vessel

  • A schematic illustration of dynamic biomechanical environments

  • Fluorescent microbead perfusion test for assessing the functionality of blood vessels

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