Mechanotransduction

Cells are able to produce, sense, and response to mechanical cues. Mechanotransduction refers to the mechanisms by which mechanical cues are converted into biochemical activities. We are specially interested in how mechanotransduction is altered in the state of diseases where the mechanical environments such as stiffness, boundary, and shape change significantly. Results of the studies are applied in understanding causes of diseases, developing new treatments, and constructing biomimetic tissue platform for drug tests.

Featured images and movies of this topic

Analysis of the effect of mechanical stretch on biological functions of cells

Fluorescent images of epithelial cells under mechanical stretch and chemical stimuli (Reference: Oh S, Chung H, Chang S, Lee SH, Seok SH, Lee H. Effect of mechanical stretch on the DNCB-induced proinflammatory cytokine secretion in human keratinocytes. Scientific Reports, Vol. 9, doi:10.1038/s41598-019-41480-y, 2019)

Movie of the motion of linear stretcher

Schematic of the stretching device

Analysis of beating motion of cilia and migration of epithelial cells under various physiological conditions

Movie of the collective migration of human airway epithelial cells (Reference: Lee SN, Ahn JS, Lee S, Lee H, Choi AMK., Yoon JH. Integrins αvβ5 and αvβ6 mediate IL-4-induced collective migration in human airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology, Vol. 60, No. 4, P. 420-33, 2019)

Analysis of the migration speed

Schematic, movie, and trajectory of the cilia beating visualized by fluorescence particle