MECHANOBIOLOGY AND SOFT MATERIALS LAB

Biomimetics

Inspired by nature, we mimic structures and systems of living species at the multiscales.  Highly ordered structures of cell are reconstituted in vitro by polymerizing cytoskeletal filaments at the environments where the mechanical, chemical or electrical conditions are similar to those in vivo. Tissue organization is replicated by culturing cells with specific patterns on a soft substrate with the physiologically-relevant stiffness. The principles learned from the biomimicry are applied to design engineering devices. Applications include an in vitro platform to test efficacy/toxicity of drugs, bio-inspired robots, and biosensors.

research4Figure – Shape-controlled single cells and tissue structures of
cardiac myocytes using the patterning technique