Mechanobiology and Soft Material Laboratory at Yonsei University seeks to understand how mechanical environments play a role in determining structures and functions of biological systems such as cells and tissues. 

Our research interests primarily lie in interdisciplinary mechanobiology at the multiscales, including protein-protein binding, cell’s response to mechanical stimulation, cell-cell coupling, cell-ECM interactions. 

Principles revealed from these studies are applied to design biomechanical devices which are useful in tissue engineering, drug delivery, bio-inspired robot, and biosensors.

Research Areas

Acoustofluidics for Particle Manipulation

We are developing acoustofluidic techniques for particle manipulation by using experimental and computational methods.

Acoustophoretic Tissue Engineering

We are developing acoustofluidic devices to fabricate functional artificial tissues for drug screening and tissue engineering. 

Biomimetic Actuator/Sensor

Inspired by nature, we mimic structures and systems of living species at the multiscales.


We are specially interested in how mechanotransduction is altered in the state of diseases where the mechanical environments such as stiffness, boundary, and shape change significantly.

     Biofilament Engineering         

We are interested in the engineering of the structure of protein network by using physical and chemical stimuli.

Mechanical Properties of Soft Materials

We characterize the mechanical properties of soft materials in terms of elasticity, plasticity, and viscosity using various techniques such as rheometry, AFM (Atomic Force Microscopy), nano-indentation, magnetic tweezers, and optical tweezers.